A cold-blooded view of adaptive immunity

A Cold-Blooded View on Adult Neurogenesis

During brain development, highly complex and interconnected neural circuits are established. This intricate wiring needs to be robust to faithfully perform adult brain function throughout life, but at the same time offer room for plasticity to integrate new information. In the mammalian brain, adult-born neurons are produced in restricted niches harboring neural stem cells. In the fruit fly Dro...

The Immunoglobulins of Cold-Blooded Vertebrates

Although lymphocyte-like cells secreting somatically-recombining receptors have been identified in the jawless fishes (hagfish and lamprey), the cartilaginous fishes (sharks, skates, rays and chimaera) are the most phylogenetically distant group relative to mammals in which bona fide immunoglobulins (Igs) have been found. Studies of the antibodies and humoral immune responses of cartilaginous f...

Oxygen Poisoning in Cold Blooded Animals

1. Exposure of frogs to atmospheres containing approximately 95 per cent of oxygen is without apparent effect on their state of well being, and produces no noticeable changes in the appearance of their web capillaries. 2. Turtles exposed to similar atmospheres are also apparently unaffected unless the oxygen be warmed to mammalian temperature. 3. At this temperature (37.5 degrees C.) the turtle...

Cold blooded vertebrates, including Xenopus laevis.

Introduction This contribution to the Symposium is mainly concerned with the South African Clawed toad, Xenopus laevis, an animal which is particularly useful for hormone assays, for studying the mechanisms of colour change, and for embryologists because of the ease with which fertile eggs and larvae can be obtained at any time of the year under laboratory conditions. The methods of handling, t...

A Unique Bacterium Pathogenic for Warm-blooded and Cold-blooded Animals